Gerard M. Turino and Jerome O. Cantor
Columbia University College of Physicians and Surgeons; St. Luke’s-Roosevelt Hospital, New York; and St. John’s University School of Pharmacy, Jamaica, New York
Conclusions:
From the perspective of published work thus far, there is evidence that HA may exert a protective effect against injury in a number of respiratory diseases. HA prevents elastin injury by elastases in vivo in hamster models of pulmonary emphysema and in vitro in elastin matrices. In addition, HA modulates neutrophil elastes secretion, stimulates or represses immunologic reactions, suppress bronchial responsiveness, and may play a role in alveolar surface structure.
